With a reputation for his frigid demeanor towards others and a deep sense of empathy during surgery, Odagiri Yuki has earned the moniker of the "Absolute Zero Angel". The ghost of a previous lover's demise continues to haunt him, leading him to self-medicate with drugs and intimacy. A neurologist named Mine takes a keen interest in Yuki's case after being requested by Kuneida to assist in curing his friend's distant attitude. Can the "Absolute Zero Angel" be thawed?